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From Inflammation to Sickness and Depression: When the Immune System Subjugates the Brain

This study included a graph similar to Figure 1 temporally relating increased autism incidence in California with increased acetaminophen use in the United States and decreased acetaminophen use with decreased rate of autism in California

McDonald, A.Z

Their method involved adding SRBCs to mouse spleen cells in Petri dishes and then charting the formation of plaques which signified the emergence of cells that secreted antibodies to the SRBCs (Mishell, Dutton)