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However, further large-scale validation and functional studies are necessary to standardize circRNA-based biomarker panels, paving the way for their integration into clinical GBM management

Given that one reaction pair could be matched with multiple reactions, for example, the reaction pair of NAD + /NADH, we performed redundancy removal based on the reaction classes

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The long-term effects on growth hormone secretion are of specific interest, as sustained rise of IGF-1 levels (whether from endogenous or exogenous sources) can suppress growth hormone release through negative feedback at the hypothalamic and pituitary levels