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Abbreviations AMPK AMP-activated protein kinase ASC alanine, serine, cysteine transporter CaMKK calcium/calmodulin-dependent protein AS160 Akt substrate of 160 kDa HNE 4-hydroxy-2-nonenal IRS insulin receptor substrate KGDH -ketoglutarate dehydrogenase LKB1 liver kinase B1 mTOR mammalian target of rapamycin PDH pyruvate dehydrogenase PDK pyruvate dehydrogenase kinase PGC-1 Peroxisome proliferator-activated receptor (PPAR) coactivator-1 PI3K phosphotidylinositide 3-kinase PP2A protein phosphatase 2A PTEN phosphatase and tensin homologue References 1.Reed LJ, De BB, Gunsalus IC, Hornberger CS., Jr Crystalline alpha-lipoic acid

Oropeza VC, Page ME, Van Bockstaele EJ

[27] [28] Polyunsaturated fatty acids, particularly arachidonic acid and linoleic acid, are primary targets for free radical and singlet oxygen oxidations

A., et al., Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles