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Specifically, the peptide downregulates inflammatory genes including interleukin-1, tumor necrosis factor-, and nuclear factor-B, while upregulating protective genes such as those encoding antioxidant enzymes, DNA repair proteins, and extracellular matrix components

Unlike classical anxiolytics, Selank has not been observed to produce sedation, dependence, withdrawal, or cognitive impairment in available research data

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Instead, their actions are often quite specific, targeting particular pathways or receptors that contribute to specific cognitive improvements

This suggests that autoimmune patients may have a natural deficiency in this regulatory peptide