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The 3-D cell model was made by culturing cells (2 10 5 1.0 10 6 ) with high glucose DMEM supplemented with 30% bovine collagen solution overnight

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Lactate and lactylation are also associated with the release of high mobility group box protein 1 (HMGB1), a damage-associated molecular pattern (DAMP), from activated macrophages 91,271

Vitamin B6 (Pyridoxine): Assists in neurotransmitter production, improving mood and cognitive function

For these reasons, new proximity labeling enzymes that use different chemistries than existing enzymes are needed to advance the field