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These findings redefine copper homeostasis as a dynamic interface between environmental stress and cell fate, offering novel biomarkers (e.g., DLAT phosphorylation and MT2A levels) and therapeutic combinations to exploit metal toxicity in cancer treatment

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In FDA guidance for research-use-only IVD products, the agency distinguishes research labeling from diagnostic positioning

Tryptophan, through its role in serotonin and kynurenine metabolism, also modulates the immune response by balancing pro-inflammatory and anti-inflammatory signals [55]

Hsu et al, 2017