Iron also contributes to adaptive mechanisms in cardiac control (Ravingerov et al., 2020), but its regulatory role in iron metabolism is often overlooked
The T112 substitution causes a reduction in levels of GSTA2-2 to around 25% of those associated with the other haplotypes S14A - inactive mutant enzyme S15A - mutant enzyme shows low isomerase activity with maleylacetone as a substrate (about 15% of wild-type) and low activity with chlorofluoroacetic acid, it shows elevated activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid as the substrate S16A - site-directed mutagenesis, G-site mutation, the mutant shows reduced activity compared to the wild-type enzyme S19A - site-directed mutagenesis, G-site mutation, the mutant shows reduced activity compared to the wild-type enzyme S200A - site-directed mutagenesis, G-site mutation, the mutant shows reduced activity compared to the wild-type enzyme T104P O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 the GSTT12B allele results from the relatively rare T104P substitution in Scandinavian individuals, and appears to destabilize the protein and result in GSTT1-1 deficiency T65M O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 naturally occuring mutation, the mutant is expressed at low levels causing GSTT1 deficiency T67A increased specific activity T68E - site-directed mutagenesis, crystal structure comparison with the wild-type isozyme GST-A1-1, overview V169 O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 naturally occuring mutation, the mutant is expressed at low levels causing GSTT1 deficiency V224I O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 a naturally occuring polymorphism common in African, Asian and European individuals V41I O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 naturally occuring mutation, catalytic activity of the V41I substitution is not evaluated but the expressed protein appears to be stable
Schistosome sirtuins as drug targets
It increases basal metabolic rate, counteracting the metabolic slowdown that typically accompanies weight loss
doi:10.3389/fonc.2020.00358 627. Ma Z, Wang D, Weng J, Zhang S, Zhang Y
