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Results DMF activates the TSS pathway in SCD erythroblasts To investigate the mechanism of DMF on ferroptosis regulation, we conducted untargeted LC-MS using erythroblasts generated from CD34+ stem cells isolated from the peripheral blood of SCD patient

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Under dual depletion of cystine and GSH, HepG2 cells underwent ferroptosis, characterized by a marked increase in lipid ROS and rescue effects of Fer-1 (Fig