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Max ROA density values in WT vs

B., Almoujahed, M

10,17 Leaving aside potential differences, including the study design, dietary regimes of control groups, housing environment, timing of food consumption and diet composition, which may have influenced the results, a clear fact is that CR is not always successful in achieving lifespan extension and may show opposing results even in very similar and well controlled studies

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Of particular interest in this regard, Marselli et al [34] analysed the transcriptome of non-diabetic donor islets exposed to glucolipotoxic stress and identified upregulated pathways associated with beta cell failure including the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress