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Senescent cells are those that have reached maturity and stopped multiplying but dont die off when they should, potentially causing damage to otherwise healthy cells

Nat Rev Neurol 1412:711722

Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions

(ii) duration

The animals used in the present study were maintained in accordance with the guidelines of the National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India and approved by the Animal Ethical Committee, Annamalai University