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These gaps highlight the need for future research to move beyond descriptive associations toward systematic dissection of integrative mechanisms, cell type-specific functions, and clinical validation

755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

The neural TRP cation channel V subfamily member 1 (TRPV1)CGRP axis regulates bone defect repair through the Hippo pathway (Jiang et al., 2023)

Bumps are usually white on light skin and grey on dark skin

The few existing clinical studies are limited by small sample sizes, and most are merely cross-sectional studies