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Furthermore, it was not until 2008 that the World Health Organization (WHO) introduced the first International Standard for IGF-1 (02/254) [115], replacing the former International Reference Reagent (IRR 87/518) that had been widely used to calibrate the majority of IGF-1 assays up until this point despite the reagents protein content having been shown to be incorrectly assigned nearly a decade earlier [116]

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