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UVRAG contains an aminoterminal prolinerich sequence followed by a potential calciumdependent phospholipid binding C2 domain, a central Beclin 1binding coiledcoil domain and a carboxyterminal region

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(PubMed) Liao F, Folsom AR, Brancati FL

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HOW INFLAMMATION LEADS TO DEPRESSION The evidence summarized in Table 2 highlights the established knowledge and recent evidence on how genetic predisposition and early life stress form a vulnerability for chronic immune dysregulation later in life, while acute infections, autoimmune disease and adverse lifestyle/metabolic factors act as triggers of sustained inflammation