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Preclinical studies supply the bulk of mechanistic information, with sparse early clinical reports for a few compounds

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In the context of pharmacokinetic investigation, the lipophilic nature of the microemulsion, the permeation-enhancing effect of chitosan, and the sol-gel transition performance collectively contributed to the ability of Hup A-ME-ISG (intranasal) to achieve higher absolute nasal bioavailability than both Hup A-ME (intranasal) and a Hup solution (intravenous)

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