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In the present study, we unveiled that methionine-derived SAM is exploited for the synthesis of UQ to maintain the integrity of mitochondrial respiratory chain, thereby methionine deprivation suppresses the accumulation of intracellular ROS that are released from electron transfer

Concurrently, PPIs, frequently prescribed to diabetic patients for gastroesophageal reflux disease management, impair protein-bound vitamin B12 release from dietary sources in the non-acidic gastric environment, with prolonged use ( 2 years) conferring a 65% increased risk of deficiency [159]

Glutathione homeostasis and functions: potential targets for medical interventions

Separate studies demonstrated anti-anxiety effects in rats at remarkably low doses (0.5 mg/kg), with effects appearing within 12 minutes and including increased exploration of open and lighted spaces, a standard measure of reduced anxiety in rodent models

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