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LRRK2 is located mainly in the cytoplasm, although approximately 10% of LRRK2 is located to the mitochondria and regulates mitochondrial function ( LRRK2 mutations in DA neurons were associated with an increased susceptibility to oxidative stress ( VPS35 Vacuolar protein sorting 35 (VPS35), composed of 796 amino acids, is a core component of the retromer complex and participates in endosomal-lysosomal transport

c , Drug synergy analysis of data shown in (a) using the ZIP model

Therefore, based on the high copper concentration in tumor tissues, depleting copper from tumor tissues or inducing excessive copper accumulation in tumor cells by disrupting their copper homeostasis using drugs and other means may induce tumor cell death in various ways

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Selenium has been shown to decrease the rate of ferroptosis when added to cells or administered to animals, including mouse models of brain hemorrhage