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Peroxisomemitochondria axis For the peroxisomemitochondria axis, the rationale is that peroxisomal -oxidation is a major H 2 O 2 source (via acyl-CoA oxidases and other flavoproteins) and peroxiporins allow H 2 O 2 to exit the organelle and coordinate with cytosolic and mitochondrial pathwaysso when flux outstrips buffering, lipid-peroxide pressure rises and spills into neighbouring compartments (Lismont et al

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Caring for people with chronic conditions: a health system perspective

10.1177/0194599815601394 Otolaryngol Head Neck Surg

Together, these findings suggest that PM can induce EMT in the airway epithelium while impairing repair mechanisms involving epithelial regeneration ( Figure 2 )