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Direct binding to neurexins and recruitment of munc18

Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

J Bone Miner Res 1996

Simultaneously, TET1/2-mediated hydroxymethylation increases 2.1-fold, suggesting active DNA demethylation responses to EED exposure (90)

krlec, K., Ruman, R., Jarc, E., Sikiri, P., vajger, U., Petan, T., Perii Nanut, M., trukelj, B., & Berlec, A