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LBDDSs have demonstrated broad applicability in oral, transdermal, topical, and systemic administration for diseases including cancer, autoimmune disorders, and dermatological conditions (Liu X

Then an equivalent number of RAW 264.7 macrophages pretreated with or without LPS/ATP and GYY4137 before co-culture were seeded in the top chamber of the insert apparatus, which was directly placed on the top of a well-containing chondrocytes

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184,185 Upregulated USP20 expression in oxaliplatin-resistant HCC cells is associated with poor prognosis, while genetic knockdown or pharmacological inhibition of USP20 can trigger ferroptosis and increase the sensitivity of HCC cells to oxaliplatin both in vitro and in vivo