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Genistein, a soy isoflavone, exerts anti-psoriatic effects by inhibiting tyrosine kinasedependent JAK/STAT signaling in keratinocytes [92]

For instance, Adcetris (Brentuximab Vedotin) employs a cleavable Val-Cit peptide linker, which utilizes lysosomal Cathepsin B cleavage to efficiently release the cytotoxic MMAE within target cells, thereby significantly enhancing efficacy

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Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic