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487,488 Increased ECM rigidity worsens the functions of senescent cells by boosting the secretion of matrix metalloproteases, intensifying ECM damage, and triggering pathways that promote senescence, fibrosis, and inflammation

Hyperglycemia results in the storage of metabolic substrates, causing the accumulation of glycolytic intermediates and the formation of mitochondrial ROS (mtROS) from the electron transport chain (ETC), ultimately inducing mitochondrial dysfunction and energy metabolism imbalance[112, 113]

e inhibe la anhidrasa carbnica (isoenzimas II y IV), de ah sus efectos sobre el estado de los electrolitos

Multidetector computed tomography (MDCT) angiography is a first-line non-invasive procedure used to assess risk of thrombosis by visualizing arterial plaque and its calcium content

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