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Upon transportation into cells, cystine can be converted into cysteine by the action of reducing agents such as glutathione (GSH) or specific enzymes like thioredoxin

Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications

Aggregate 5 , e458 (2024)

Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible

These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]