what are the potential side effects of 5-amino-1mq Selective and membrane-permeable small molecule inhibitors nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice 5-AMINO-1MQ - Beverly Hills Rejuvenation

Obesity 31 , 111122 (2023)

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) the enzyme that methylates nicotinamide (NAM) to 1-methylnicotinamide (1-MNA) using S-adenosyl-methionine (SAM) as the methyl donor

A study published in the Journal of Pharmaceutical Sciences found that oral peptide bioavailability decreased by 3542% when administered within four hours of a meal compared to true fasted-state dosing

Methionine is an amino acid found in eggs, fish, spinach, sesame seeds, potatoes, etc

Estrogens, tri-iodothyronine, and dexamethasone are the nuclear hormones that have been tested