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Indeed, two ERK1/2-inducible proteins, JunB and sprouty-2 (Spry2), were also highly up-regulated in the airway tissue of asthmatic patients, with prominent JunB expression, a member of the AP-1 transcription factor complex (Sripada et al

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In practice, the order of steps proposed is unlikely to be entirely linear as drug discovery often follows a meandering path where the improvements to one property often results in the worsening of another