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Intriguingly, this effect required continuous exposure to APAP, as animals fed APAP overnight (to simulate a brief/singular dose) showed a mild reduction in survival, but the reduction in survival was not as significant as those who experienced continuous exposure (Supplemental Fig

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Raju, M.V.L.N., and G

The reaction is initiated by the abstraction of a hydrogen radical and is followed by addition of oxygen to give a cyclic endoperoxide, before addition of a further oxygen molecule forms the hydroperoxide

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