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59 A cycle of tissue breakdown and repair is seen in engrafted ectopic lesions in endometriosis mouse models of endometriosis 60 , 61 (see Figure 1 below)

While the majority of the ALS cases (~9095%) are considered as sporadic (sALS) with unknown cause, ~510% cases involve Mendelian pattern of inheritance of familial gene mutations and are known as familial ALS (fALS) (Renton et al., 2014