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Given the dominant contribution of oxidative stress to mitochondrial dysfunction in AP, mitochondria-targeted antioxidants have also been investigated as a means to protect mitochondriaorganelle crosstalk

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doi: 10.1034/j.1399-3003.2000.16b12.x

83,84 Mitochondrial metabolism Mitochondria play a central role in substance metabolism, overseeing a vast array of metabolic processes as depicted in Fig

ACTH is a peptide hormone produced by the anterior pituitary that primarily stimulates cortisol production from the adrenal cortex, but fragments of ACTH (particularly the N-terminal fragments) have been recognized since the 1970s to possess neurotrophic and cognitive-enhancing properties independent of their effects on the adrenal cortex