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10.1016/0891-5849(92)90184-i Free Radic

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It might be a vitamin B12 deficiency, which can easily go months without anyone noticing

Mitochondrial dysfunction has been recognized as an early pathogenic event for ASD [354] and AD [355], which significantly impairs brain function, as we discuss above

KYNA can confer protection against excitotoxicity via glutamatergic antagonism, yet excessive levels may simultaneously impair cholinergic signalling through 7nAChRs, contributing to mood and cognitive dysfunction