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Several studies have evaluated oral and topical GSH for general skin lightening

Journal of Experimental Medicine 212 , 14331448 (2015)

ROS are produced in mitochondria (mainly via the electron transport chain, where ~12% of O 2 is reduced to form superoxide anions), peroxisomes (through the -oxidation of fatty acids) and the endoplasmic reticulum (through the oxidation of proteins)

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