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4.3 Renal fibrosis and extracellular matrix remodeling Renal fibrosis is the common pathological endpoint of various chronic kidney diseases (CKD) and is characterized by fibroblast activation, epithelial-to-mesenchymal transition (EMT), and abnormal accumulation of the extracellular matrix (ECM), ultimately leading to nephron destruction and loss of function ( -SMA and collagen I, promoting interstitial remodeling

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The next sections will detail how polyphenolic compounds contribute to the reduction of ROS levels, mainly in the pathways that inhibit ROS generation and promote the elimination of existing ROS in the body (Fig

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