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31 , 148161.e145 (2020)

Martin-Facklam et al

Notably, a decrease in deuterium uptake was also observed for residues 3447, which do not directly interact with SH3 in the structure but are located near the arr1-N site, suggesting that SH3 binding may indirectly stabilize this region

doi: 10.3389/fphar.2021.657033 Received 22 January 2021 Accepted 19 May 2021 Published 04 June 2021 Volume 12 - 2021 Edited by Philippe De Deurwaerdere, Universit de Bordeaux, France Reviewed by Habibeh Khoshbouei, University of Florida, United States Gaiqing Wang, The Third Peoples Hospital of Hainan Province, China Updates Copyright 2021 Tan, Fang and Gu

The inhibition of the GPX3 gene leads to a decrease in the ability of tumor cells to survive without anchorage and a reduced capacity to respond to external oxidative stress