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Recent clinical trials in patients with schizophrenia suggest that treatment with PREG as add-on therapy alleviates cognitive deficits ( A Rs) are elevated, suggesting a possible role for PregS in improvement of learning and memory function ( Neurosteroids, Dopamine Knockout Mouse Model and Schizophrenia Dopamine (DA) is a neuromodulator and a key player in several neural disorders in which cognitive deficits are characteristic, such as schizophrenia, attention deficit hyperactivity disorder, and depression (379381)