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Oral mucosal melanin hyperpigmentation associated with syndromes and systemic diseases Oral mucosal melanin hyperpigmentation is often observed in the systemic conditions such as Peutz-Jegher syndrome, McCune-Albright syndrome, Laugier-Hunziker syndrome, Addison disease, and neurofibromatosis

Indeed, it has been suggested that certain cytokines that are upregulated during HIV infection have the capacity to induce the production of -MSH by oral melanocytes and keratinocytes and to mediate the upregulation of expression of MC1R by melanocytes, resulting in increased melanin production

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PT-141 (Bremelanotide) activates melanocortin receptors MC1RMC5R within the central nervous system