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Many inflammatory factor-related signaling pathways are also involved in these diseases, such as the NF-B and p38/ERK1/2/MAPK pathways

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PURINERGIC SIGNALING, CLINICAL IMPROVEMENT, AND NEUROLOGICAL DEFICITS Associations between purine metabolites and clinical and neurological symptoms were examined before and after 4w antipsychotic treatment (Yao et al., 2012)

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Additionally, in hypoxia-induced PAECs and MCT-PAH rats, activation of the p38 pathway increases m and hyper-polarization by elevating MK2 expression, resulting in increased levels of mitochondrial ROS