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Published trials used oral doses of 0.25 mg to 30 mg per day and intravenous single doses of 25 to 400 mcg/kg

Key Research Properties: Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor Modulates NAD+ metabolism and methylation capacity Studied in context of energy expenditure and metabolic regulation NNMT is upregulated in obesity

Unlike full-length growth hormone, AOD-9604 does not upregulate IGF-1, does not induce insulin resistance in reported toxicology models, and does not measurably affect linear growth in adult animal models

The rodent data is real, but the pivotal 534-subject obesity trial did not beat placebo and development stopped in 2007

endorse any use outside of controlled laboratory environments