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Mechanotransduction involves the conversion of mechanical signals into biochemical responses, leading to cellular adaptations that strengthen the ligament

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This process involves the promotion of Lactobacillus , Romboutsia , Dubosiella, Barnesiella, Thermomonas , and Akkermansia , while concomitantly inhibiting the growth of Bacteroidota , Providencia sp ., and Vibrio

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In a recent paper by Pascaud et al [19] the density of the barrier was reduced to 1.20 g/ml, i.e