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Science 350 , 830834 (2015)

Glucose metabolism by mitochondrial oxidative phosphorylation is the main bioenergetic pathway that supports osteoclast differentiation, but increased glycolytic activity promotes osteoclast differentiation (232)

Supporting these results, a recent cross-sectional study of hospital workers reported that leukocyte telomere length was positively associated with plasma PTX3 levels, suggesting that efficient regulation of inflammatory processes may protect telomeres from attrition, even in NS workers 144

Such mitochondrial effects allow the evaluation of a wide range of human illnesses (55, 56)

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