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435 Gain of function of sodium channels leads to increased neuronal excitability, signal transduction, and neurotransmitter release

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Increased serum creatinine was reported in patients with 1) underlying renal disease, 2) dehydration secondary to fever, sepsis, gastrointestinal losses, or diuretic therapy, or 3) other risk factors, such as advanced age, or concomitant nephrotoxic drugs in the post-infusion period

Additionally, as one clinical drug used to inhibit cancer development, selenite combined with LSP regulated the GPX4/GSH pathway to promote ferroptosis in hepatocellular carcinoma and enhanced hepatocellular carcinoma cell sensitivity to selenite (Lin, 2024)

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