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Cyclodextrins control the release of the drug due to mucoadhesive properties or by adjusting the hydrophobicity of the guest molecule [48,49]

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The foundational U-shaped dose-response relationship was also documented in this original research programme

Additional refinements to its structure to limit both phase 1 and phase 2 hepatic metabolism and first pass clearance, to reduce metabolism by gastric enzymes and enhance oral bioavailability, and to diminish polar surface area and overall size to facilitate BBB penetrability are currently in progress

Yes, FOXO4-DRI is related to the forkhead peptide family