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At therapeutic dosing, NAPQI binds to nucleophilic glutathione

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Glutamic acid, along with glutamine, proline, histidine, arginine and ornithine, belongs to a family of related amino acids known as the glutamate amino acids

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In contrast to VitC, which is slowly imported via sodium-dependent vitamin C transporter-2 (SVCT-2) and maintained at high steady-state concentrations in the brain 6 , DHA is a transient species with remarkably different transport properties despite its structural similarity to VitC