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Ebselen effectively promotes SGN survival and prevents SGN apoptosis after peroxynitrite injury by reducing SGNs oxidative stress, while the absence of GPX1 in gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice

Furthermore, the knockdown of BIM EL abolished the effect of the combined treatment [105]

Small volumes of lysate were taken to measure total protein concentration, using absorbance at 280 nm in triplicate by Nanodrop

Inclusion and exclusion criteria The inclusion criteria were as follows: (1) full-text articles

Do not use the injection if the beyond-use date has passed or if the solution appears discolored, cloudy, or contains precipitate