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Changes in the epigenetic landscape of monocytes leading to BDG-induced trained immunity are mediated by the activation of mechanistic target of rapamycin (mTOR) and hypoxia-inducible factor 1 (HIF-1)

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For instance, Puer tea polysaccharide (137) and Gastrodia elata polysaccharide (138) demonstrate potent antioxidant activity, while polysaccharides from lichii and Ampelopsis grossedentata, rich in uronic acid, show similar efficacy (139)

5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig