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This creates a vicious cycle: the oxidative stress further damages the mitochondrial DNA and lipid membranes, which in turn causes even more mitochondrial dysfunction and energy depletion

After 24 h of incubation, 1 ml of the upper-medium was drawn before collecting the cells to measure the concentration of cobalt in the extracellular solution

Therefore, it is necessary to conduct large-scale clinical trials to evaluate the clinical effects of anti-CAFS drugs and to find more specific CAFs targets

Deng H, Yue JK, Zusman BE, Nwachuku EL, Abou-Al-Shaar H, Upadhyayula PS

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