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Nevertheless, although a specific action of homocysteine seems to occur at low concentrations, experimental trials have been conducted only with homocysteine administration, which would reflect a severe hyperhomocysteinemia rather than a more physiologic moderate elevation of circulating homocysteine, and clinical observations have only come from homocystinuric patients with severe hyperhomocysteinemia

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During disease progression, the accumulation of aberrant proteins can overwhelm the cellular chaperone system, as the demand for refolding and clearance exceeds its capacity 97

Another known cause of cobalamin deficiency is Diphyllobothrium latum (D

Several studies reported that children with a history of TBI injury have decreased hippocampal volumes [4, 5]