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The foundational study is Neelakantan and colleagues, 2018 , in Biochemical Pharmacology

Medical clearance ensures all concussion symptoms have completely resolved, and brain function has returned to pre-injury levels

IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells

However, the activity of p53 is positively regulated by the alternative reading frame tumor suppressor (ARF), an upstream molecule that suppresses the MDM2 activity (73)