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Targeting active molecules to the mitochondria is likely to improve their effectiveness against oxidative insult and hence be beneficial for FRDA patients due to reduced off-target therapy, increased specificity and lower therapeutic dosage required of the targeted chelator (Reelfs, et al., 2019

Ethics approval and consent to participate The "Guide for the Care and Use of Laboratory Animals" and the Ethical Committees approval of the Faculty of Science, Suez University, Suez, Egypt, for the use of animal subjects guidelines were followed in all experimental procedures

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J Exp Bot 49(329):18951908

Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: Structural and kinetic aspects