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Intestinal microbial imbalance can affect the function of the HPA axis, leading to systemic inflammation and immune dysfunction

Acknowledgements This work was supported by the National Key Research and Development Program of China (2024YFC2418800, 2022YFC2504300), the National Natural Science Foundation of China (92468107, 82422045, 82102593, and 82402814), the Capitals Funds for Health Improvement and Research Program by Beijing Municipal Health Commission (2024-2-5052), the Beijing Natural Science Foundation (L256032, 7262117), PLA General Hospital Youth Independent Innovation Science Fund project (22QNFC041), and the China Postdoctoral Science Foundation (XJ2021051)

L.Goncalves NettoA.NicolaiM.CarvalhoS

It can not only regulate the activity of neutrophils and dendritic cells, but also regulate the proliferation and activity of T cells

Experimental protocols vary widely, with differences in CP dosing schedules, timing, and duration of protective agent treatment, and choice of endpoints (Kim and You 2021)