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In summary, advancing the field of human neuroprotection demands a multidimensional recalibration, spanning conceptual clarity, more representative preclinical models, validated biomarkers, and refined clinical endpoints

Kade IJ, Balogun BD, Rocha JB

To monitor and modulate integration and circuit engagement of hPS cell-derived DA neurons, a clozapine- N -oxide (CNO)-responsive designer receptors exclusively activated by designer drug (DREADDs) cassette was inserted via CRISPR knock-in, allowing the chemogenetic activation or inhibition of grafted cells 92

Activated charcoal, 1 g/kg, should be administered every 4 hours if it can be given safely

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