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Establishing a separate weekly bundled payment is also more appropriate because weekly injectable buprenorphine requires more frequent administration costs than monthly injectable buprenorphine (weekly Brixadi must be injected at least once every 7 days compared to once a month for Sublocade and monthly Brixadi)

The different mechanisms of action theoretically could be complementary, but without clinical studies, such combinations represent unknown risks that most healthcare providers wouldn't recommend

James KellerShabrokh, D.O

This suggests a temporary effect on blood pressure regulation or hydration status rather than a direct neurological impact