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Some patients experience fluid retention, particularly early in the protocol

Drug metabolism reviews, 46(3), 261-282

If there is a complete tear within the muscle, the torn ends are reattached using stitches

For instance, amifostine exhibits remarkable individual differences in efficacy and toxicity: it requires alkaline phosphatase (ALP) for conversion in vivo to exert its effects, and varying ALP levels among tumor patients affect the production of its active metabolites, thereby influencing therapeutic efficacy (192)